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KMID : 0604520170430040289
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Journal of the Society of Cosmetic Scientists of Korea
2017 Volume.43 No. 4 p.289 ~ p.295
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Anti-melanogenesis Activities for the Terpenes from the Acantophanax koreanum Stems
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Mun Seung-Ri
Hyun Ju-Mi
Jo Yeong-Jeong
Jung Eun-Young
Lee Nam-Ho
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Abstract
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A. koreanum was investigated to identify the constituents possessing whitening effects. As anti-melanogenesis activities were screened for the ethanol extract and solvent fractions, n-hexane (Hex) and ethyl acetate (EtOAc) fractions showed the most potent activities. Three constituents were isolated from the n-Hex fraction of A. koreanum; kaurenoic acid (1), 16α-hydro-17-isovaleroyloxy-ent-kauran-19-oicacid (2), 16α-hydroxy-17-isovaleroyl-oxy-ent-kauran-19-oic acid (3). The chemical structures of the isolated compounds were elucidated based on the spectroscopic data including 1H and 13C NMR spectra, as well as comparison of the data to the literature values. Whitening effects were studied for the isolated compounds. Upon the anti-melanogenesis test using α-MSH stimulated B16F10 melanoma cells, the compounds 1, 2 and 3 inhibited the cellular melanogenesis and intracellular tyrosinase activities effectively. Based on these results, A. koreanum stems extract could be potentially applicable as whitening ingredients in cosmetic formulations.
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KEYWORD
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A. koreanum, whitening, anti-melanogenesis, constituents
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